Phenytoin

Phenytoin is a medicine used to treat epilepsy.

It can also be used to treat trigeminal neuralgia, a type of nerve pain that affects your face.

Phenytoin is available on prescription. It comes as tablets that can be chewed or dissolved in water, capsules and a liquid that you swallow.


  • It's usual to take phenytoin once or twice a day. You can take it with or without food.
  • The most common side effects of phenytoin are headaches and dizziness.
  • It takes around 4 weeks for phenytoin to work.
  • The most common brand names are Epanutin and Epanutin Infatabs.

Phenytoin can be taken by adults and children of any age.

Phenytoin is not suitable for some people.

To make sure phenytoin is safe for you, tell your doctor if you:

  • have ever had an allergic reaction to phenytoin or other medicines in the past
  • have liver or kidney problems
  • have a blood disorder called porphyria
  • cannot have alcohol - phenytoin liquid contains a small amount of alcohol
  • have had a rash caused by phenytoin in the past
  • are pregnant or planning to become pregnant
  • have ever had an allergic reaction to carmoisine (E122) or sunset yellow (E110) - some brands of phenytoin liquid and tablets contain these
  • have an intolerance to or cannot absorb some sugars - some brands of phenytoin tablets contain sugars

Phenytoin is a prescription medicine. It's important to take it as advised by your doctor.

How much will I take?

The usual dose of phenytoin to treat epilepsy in:

  • adults is between 200mg and 500mg a day, taken as 1 or 2 doses
  • children (aged 12 to 17 years) is between 300mg and 400mg, taken as 2 doses
  • children (aged up to 11 years) varies depending on their weight

The usual dose to treat trigeminal neuralgia in adults is between 300mg and 500mg a day, taken as 1 or 2 doses.

How to take it

It's usual to take phenytoin once or twice a day. You can take it with or without food.

If you take it twice a day, try to space your doses evenly through the day. For example, first thing in the morning and in the evening.

Capsules and tablets - swallow whole with a glass of water, milk or juice. Do not chew them.

Chewable tablets - can be swallowed whole with a glass of water or chewed.

Liquid - this comes with a syringe or spoon to help you measure it. If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give you the right amount.

Will my dose go up or down?

To prevent side effects, your doctor will prescribe a low dose to start with and then increase it over several weeks.

You might need to have blood tests when you start phenytoin or if your dose is changed. This is to make sure your dose is right.

Once you find a dose that suits you, it'll usually stay the same.

How long will I take it for?

If you have epilepsy, it's likely that once your condition is under control you'll still need to take phenytoin for many years.

If you have trigeminal neuralgia, phenytoin will be continued for as long as necessary, sometimes many years, unless your pain gets better or disappears altogether.

Do not stop taking phenytoin without talking to your doctor first.

What if I forget to take it?

If you take phenytoin and miss a dose:

  • once a day - take the missed dose as soon as you remember. If it's less than 12 hours before the next dose is due, it's better to leave out the missed dose and take your next dose as normal.
  • twice a day - take the missed dose as soon as you remember. If it's less than 8 hours before the next dose is due, it's better to leave out the missed dose and take your next dose as normal.

Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.

If you have epilepsy, it's important to take this medicine regularly. Missing doses may trigger a fit (seizure).

If you forget doses often, it may help to set an alarm to remind you.

You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

Taking too much phenytoin by accident can cause unpleasant side effects.

Call your doctor or go to A&E straight away if you take too much phenytoin and:

  • get fast, uncontrollable eye movements
  • feel clumsy and lose your balance
  • get slurred speech
  • have problems breathing
  • pass out

If you need to go to A&E, do not drive yourself. Get someone to drive you or call for an ambulance.

Take the phenytoin packet or the leaflet inside it, plus any remaining medicine, with you.

Like all medicines, phenytoin can cause side effects, although not everyone gets them.

Skin rashes

It's common to get a skin rash with phenytoin. Most skin rashes are not serious.

But if you develop a skin rash or redness, tell a doctor straight away, as this can develop into a life-threatening skin condition called Stevens-Johnson syndrome.

Stevens-Johnson syndrome is a rare side effect of phenytoin.

It causes flu-like symptoms, followed by a red or purple rash that spreads and forms blisters. The affected skin eventually dies and peels off.

It's more likely to happen in the first 8 weeks of starting phenytoin, or when the dose is increased too quickly.

It can also happen if phenytoin is stopped suddenly for a few days and then restarted at the same dose as before, without reducing the dose and then increasing it slowly again.

Stevens-Johnson syndrome is more common in:

  • children
  • people who have developed a rash before with a different epilepsy medicine
  • people who are allergic to an antibiotic called trimethoprim
  • people also taking a medicine called sodium valproate

To help prevent the chance of you getting a rash that could be confused with Stevens-Johnson syndrome, it's best to not start any new medicines, foods or products during the first 3 months of treatment with phenytoin.

It's also best to not start phenytoin within 2 weeks of a viral infection, vaccination or rash caused by something else.

Common side effects

These common side effects may happen in more than 1 in 100 people. They're usually mild and go away by themselves.

Keep taking the medicine and talk to your doctor or pharmacist if these side effects bother you or do not go away:

  • headaches
  • feeling drowsy, sleepy or dizzy
  • feeling nervous, unsteady or shaky
  • feeling or being sick (nausea or vomiting)
  • constipation
  • sore or swollen gums
  • mild skin rash

Some side effects of phenytoin wear off once your body gets used to the medicine, but it can take several weeks or months.

Serious side effects

Very few people taking phenytoin have serious problems.

Tell your doctor straight away if you have a serious side effect, including:

  • thoughts of harming or killing yourself - a small number of people taking phenytoin have had suicidal thoughts, which can happen after a few weeks of treatment
  • unexpected bruising or bleeding, a high temperature or sore throat - these could be warning signs of a blood disorder
  • a high temperature with swollen glands and a skin rash, sometimes with yellowing of your skin or the whites of your eyes, particularly in the first 2 months of treatment - these may be signs of a hypersensitivity reaction, which is more likely to happen if you're black African-Caribbean or have a weakened immune system
  • your seizures get worse if you take phenytoin for epilepsy
  • a skin rash - this might be a sign of Stevens-Johnson syndrome

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to phenytoin.

Contact a doctor straight away if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

These are warning signs of a serious allergic reaction.

A serious allergic reaction is an emergency.

These are not all the side effects of phenytoin.

For a full list, see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

What to do about:

  • headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. If it's a problem, ask your pharmacist to recommend a painkiller. Talk to your doctor if your headaches last longer than a week or are severe.
  • feeling drowsy, sleepy or dizzy - as your body gets used to phenytoin, these side effects should wear off. Do not drive, ride a bike or operate machinery until you feel more alert. If they do not go within a week or two, your doctor may reduce your dose or increase it more slowly. If that does not work, you may need to switch to a different medicine.
  • feeling nervous, unsteady or shaky - talk to your doctor if this bothers you. These symptoms can be a sign that the dose is too high for you.
  • feeling or being sick - stick to simple meals and do not eat rich or spicy food. It might help to take your phenytoin after a meal or snack. If you're being sick, try taking small, frequent sips of water to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee. Speak to a doctor if your symptoms get worse or last more than week.
  • constipation - eat more high-fibre foods, such as fresh fruit and vegetables, and cereals. Try to drink several glasses of water or another non-alcoholic liquid each day. If you can, try to exercise more regularly - for example, by going on a daily walk or run.
  • sore or swollen gums - brush your teeth and gums twice a day to help stop this happening, and visit your dentist regularly
  • mild skin rash - it may help to take an antihistamine, which you can buy from a pharmacy. Check with the pharmacist to see what type is suitable for you. Use lukewarm water rather than hot in the shower. Contact your doctor if it spreads, gets very itchy or lasts more than a couple of days.

Phenytoin has been linked to an increased risk of problems for your unborn baby.

You'll usually only be advised to take it if your doctor thinks the benefits of the medicine outweigh the risks.

It's important that you and your baby stay well during pregnancy.

If you take phenytoin and become pregnant, tell your doctor or nurse straight away.

If you have epilepsy, it's very important that it's treated during pregnancy as seizures can harm you and your unborn baby.

Do not stop taking it without talking to your doctor first.

If you're pregnant or trying to get pregnant and taking phenytoin, you're recommended to take a higher dose of folic acid, a vitamin that helps your baby grow normally.

Your doctor might prescribe a high dose of 5mg a day for you to take when you're trying to get pregnant and during the first 12 weeks of pregnancy.

Phenytoin and breastfeeding

If your doctor or health visitor says your baby is healthy, phenytoin can be taken while you're breastfeeding.

Phenytoin passes into breast milk in small amounts. There have been some reports of side effects in breastfed babies, but in most cases babies do not get any side effects.

It's important to keep taking phenytoin to keep you well. Do not stop taking it without talking to your doctor.

Breastfeeding will also benefit both you and your baby.

If you notice that your baby's not feeding as well as usual, seems unusually sleepy, or you have any other concerns about them, talk to your pharmacist, health visitor or doctor as soon as possible.

Talk to your doctor if you're:

  • trying to get pregnant
  • pregnant
  • breastfeeding

There are lots of medicines that can interfere with phenytoin and increase the chances of you having side effects.

If you need to take these medicines, your doctor may change your dose of phenytoin.

Tell your doctor if you're taking:

  • other medicines used to treat epilepsy, such as carbamazepine, clonazepam, lamotrigine, phenobarbital, sodium valproate, topiramate, oxcarbazepine, ethosuximide and vigabatrin
  • medicines used to treat HIV
  • hormonal contraceptives or hormone replacement therapy (HRT)
  • medicines used for heart and circulation problems - like digoxin, amiodarone, furosemide, warfarin, diltiazem, nifedipine, apixaban and ticagrelor
  • medicines used to treat fungal infections - like fluconazole, itraconazole and miconazole
  • medicines used for tuberculosis and other infections - like isoniazid, rifampicin, sulfamethoxazole-trimethoprim, doxycycline and ciprofloxacin
  • medicines used for stomach problems - like omeprazole, sucralfate, ranitidine and some antacids
  • theophylline - a medicine to help with breathing problems
  • medicines used for sleeplessness and mental health problems - like chlordiazepoxide, clozapine, clobazam, diazepam, disufiram, fluoxetine, quetiapine, trazodone and amitriptyline
  • medicines used for transplants - such as ciclosporin and tacrolimus
  • medicines used for cancer
  • upropion - a medicine to help you stop smoking

This is not a full list of medicines that interfere with phenytoin.

For a full list, see the leaflet inside your medicines packet.

Mixing phenytoin with herbal remedies and supplements

There may be a problem taking some herbal remedies and supplements alongside phenytoin.

Do not take St John's wort with phenytoin, as it decreases the amount of phenytoin in your blood.

If you already take it, talk to your doctor before stopping St John's wort as they may need to increase your phenytoin dose.

Important

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

How does phenytoin work?

For epilepsy - brain cells normally "talk" to each other using electrical signals and chemicals.

Seizures can happen when the brain cells are not working properly or working faster than normal.

Phenytoin slows down these electrical signals to stop seizures.

For nerve pain - phenytoin was not originally designed to treat pain, but it can help to relieve nerve pain, such as trigeminal neuralgia, by slowing down electrical impulses in the nerves and reducing their ability to transmit pain.

How long does it take to work?

It usually takes around 4 weeks for phenytoin to work properly.

This is because the dose of phenytoin needs to be increased slowly to prevent side effects.

You may still have seizures or pain during this time.

Is it safe to take phenytoin for a long time?

Many people can take phenytoin safely for several months or years.

But there are some side effects that might happen over a long time.

Long-term treatment with phenytoin can:

  • decrease the amount of vitamin D in your blood and might lead to osteoporosis and osteopenia, increasing your risk of breaking a bone. If the amount of vitamin D in your blood is low, your doctor will give you vitamin D supplements.
  • cause nerve damage (peripheral neuropathy), which can lead to symptoms such as numbness and tingling in hands or feet
  • make the skin on your face look and feel coarse and become slightly hairy
  • affect your ability to think clearly, especially in children

Are there similar medicines?

There are lots of other medicines that can be used for epilepsy and trigeminal neuralgia, but they work in different ways.

They might have different side effects, or be taken more or less often.

If you have epilepsy, the choice will depend on the type of seizures that you have.

Your doctor will discuss the best medicine for you.

If you have trigeminal neuralgia, other medicines that your doctor might use include carbamazepine and gabapentin.

Do I need to stay on the same brand of phenytoin?

If you have epilepsy, it's best to stay on the same brand of phenytoin, as other brands of phenytoin may not work as well for you.

If you take phenytoin for trigeminal neuralgia, most people do not have to stay on the same brand.

Talk to your doctor or pharmacist if you cannot get a supply of your normal brand of phenytoin.

How does phenytoin compare with other medicines for epilepsy?

There are many different medicines for treating epilepsy.

It's not possible to say that one works better than the other.

It varies from person to person, and depends on the type of seizures and how often you have them.

Other epilepsy medicines include:

Before prescribing a medicine, your doctor will also take into account your age and gender, the medicines you're already taking and any other health problems you may have.

It's usual to try to treat epilepsy using a single medicine.

If this medicine is not working well or you're getting side effects, your doctor will usually try you on a different one.

If a single medicine is not preventing your seizures, your doctor may recommend taking 2 or more epilepsy medicines at the same time.

How does phenytoin compare with other medicines for trigeminal neuralgia?

An epilepsy medicine called carbamazepine is usually the first medicine given to treat trigeminal neuralgia.

Phenytoin might be used if carbamazepine does not work or causes too many side effects.

Some other medicines may be used to treat trigeminal neuralgia. Your doctor or specialist will find the medicine that works best for you.

Can I switch to a different medicine?

If you're switching medicines, it's very important to do it exactly as your doctor tells you to.

If you want to switch, you'll usually start taking the new one at a low dose and slowly build up the dose while you're still taking phenytoin.

Once you're taking the correct dose of the new medicine, you should be able to slowly reduce your dose of phenytoin.

It can take several weeks or months until you have stopped taking phenytoin completely.

How can I come off phenytoin?

If you're taking phenytoin for epilepsy, stopping it suddenly can cause seizures.

Coming off phenytoin should be done very slowly and might take a few months.

If you're taking phenytoin for trigeminal neuralgia and your pain goes away, your doctor will slowly reduce your dose as low as possible, or may even stop it.

If you get a serious side effect, such as a severe skin rash, your doctor may tell you to stop taking phenytoin straight away, even if you have epilepsy.

Important

Do not stop taking phenytoin without talking to your doctor first.

Will I need blood tests while taking phenytoin?

Your doctor may measure the amount of phenytoin in your blood:

  • when you first start taking it
  • when you change your dose
  • if you need to change to a different form of phenytoin (for example, if you change from tablets to the liquid)

The blood tests will help your doctor to decide what dose is right for you and if they need to increase or decrease your dose.

Can I take phenytoin before surgery?

You can take phenytoin as normal on the day of your surgery, unless your doctor or surgeon has advised you not to.

Will it affect my contraception?

You can use the contraceptive injection or coil safely with phenytoin.

Phenytoin might stop these contraceptives working:

  • combined hormonal contraceptives (the combined pill, patches and vaginal ring) - look out for bleeding between periods, which might be a sign the pill is not working. Talk to your doctor if this happens. Your doctor may advise you to use a different type of contraceptive, or condoms as well as combined hormonal contraception.
  • progestogen-only contraceptive pill and implants - your doctor may advise you to use a different type of contraceptive that's not affected by phenytoin
  • emergency contraception - tell your doctor or pharmacist that you take phenytoin if you need emergency contraception. You may need an increased dose or to use the copper coil.

Will it affect my fertility?

It's not thought that phenytoin affects female fertility.

For some men with epilepsy, epilepsy medicines can reduce levels of testosterone.

It does not affect everyone, but it could make you less fertile.

Speak to your doctor if you have any concerns.

Does phenytoin cause weight loss ?

Phenytoin does not usually affect weight at all.

Can I get epilepsy medicines for free?

If you have epilepsy, you're entitled to free prescriptions for all of your medicines, not just your epilepsy ones.

To claim your free prescriptions, you'll need a medical exemption certificate.

The application form for the medical exemption certificate is called FP92A.

You can get this from your doctor's surgery.

You'll need to fill in the form, and your doctor will sign it and send it off.

Can I drink alcohol with it?

Yes, you can usually drink alcohol with phenytoin.

But it may make you feel sleepy or tired, and alcohol and hangovers can bring on seizures in some people with epilepsy.

During the first few days of taking pheyntoin, it's best to stop drinking alcohol until you see how the medicine affects you.

Talk to your doctor about how much alcohol you drink. They may do blood tests to check everything is OK.

If you do drink, try not to have more than the recommended guidelines of up to 14 units of alcohol a week.

A standard glass of wine (175ml) is 2 units. A pint of lager or beer is usually 2 to 3 units of alcohol.

Is there any food or drink I need to avoid?

No, you can eat and drink normally while taking phenytoin.

Can I drive or ride a bike with it?

You may feel sleepy or dizzy when you first start taking phenytoin or the dose is increased.

If this happens to you, do not drive or ride a bike until you feel more alert.

Phenytoin can also affect your vision. Do not drive or ride a bike if your vision is affected.

If you have epilepsy, you're not allowed to drive until you have had no seizures for 1 year.

You're not allowed to drive for 6 months after changing your epilepsy medicine.

GOV.UK has more information on epilepsy and driving

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