Co-codamol for adults

Co-codamol is a mixture of 2 different painkillers - paracetamol and codeine.

It's used to treat aches and pains including headaches, muscular pain, migraines and toothache.

It's usually taken when everyday painkillers, such as aspirin, ibuprofen and paracetamol alone, haven't worked.

This medicine comes as tablets and capsules.

For children under 16 years of age, read our information on co-codamol for children.

  • Co-codamol tablets and capsules come in 3 strengths. You can buy the lowest strength co-codamol from pharmacies but the higher strengths are only available on prescription.
  • The most common side effects of co-codamol are constipation, feeling sick and sleepiness.
  • Taking too much co-codamol can be harmful. Don't be tempted to increase the dose or take a double dose if your pain is very bad.
  • It's possible to become addicted to the codeine in co-codamol, but this is rare if you're taking it as a painkiller under medical supervision.
  • Co-codamol is also known by many different brand names. Talk to your pharmacist if you have any questions about different brands.

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Co-codamol can be taken by anyone aged 12 years or over, but for under-16s, read our information on co-codamol for children. Under-18 year-olds should only take it if other painkillers haven't worked.

Co-codamol isn't suitable for some people. Tell your doctor before starting the medicine if you:

  • have lung problems or breathing difficulties
  • have a head injury
  • have adrenal gland problems
  • have an illness which causes fits
  • regularly drink more than the maximum recommended amount of alcohol (14 units a week)
  • are trying to become pregnant, are already pregnant or are breastfeeding - co-codamol is not usually recommended in pregnancy or while breastfeeding
  • have liver problems
  • are less than 18 years old and have had your tonsils or adenoids removed because of a sleep problem called obstructive sleep apnoea syndrome

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Co-codamol comes as tablets and capsules. Swallow them whole with a drink of water, with or without food.

Co-codamol also comes as soluble tablets that dissolve in water to make a drink.

Different co-codamol strengths

Co-codamol tablets and capsules come in 3 different strengths.

They contain 8mg, 15mg or 30mg of codeine.

All 3 strengths contain 500mg of paracetamol - the same as in a standard paracetamol tablet or capsule.

The strength of co-codamol appears as 2 numbers on the packet. For example, the strength may be written as 8/500. This means it contains 8mg of codeine and 500mg of paracetamol.

You can buy the lowest strength of co-codamol (8/500) without a prescription, but only from a pharmacy. The higher strengths (15/500 and 30/500) are only available on prescription from a doctor.

How much to take

The normal dose for pain in:

  • teenagers aged 16 years to 18 years is 1 or 2 tablets (of any strength) up to 4 times in 24 hours. Always leave at least 6 hours between doses. The maximum dose is 8 co-codamol tablets in 24 hours.
  • adults over the age of 18 is 2 co-codamol tablets (of any strength) up to 4 times in 24 hours. Always leave at least 4 hours between doses. The maximum dose is 8 co-codamol tablets in 24 hours.

It's important to leave a gap between doses of co-codamol. Taking too much co-codamol can be very dangerous. That's because the paracetamol in it can cause liver damage. Don't increase the dose of co-codamol or take a double dose if your pain is very bad.


The maximum dose of co-codamol for an adult aged 16 years and over is 8 tablets in 24 hours.

How long to take it for

If your doctor has prescribed co-codamol for you, take it as you've been advised.

If you've bought co-codamol from a pharmacy, don't use it for more than 3 days. If you still have pain, talk to your pharmacist or doctor.

What if I take too much?

If you take 1 or 2 extra tablets of co-codamol by accident on a single occasion, it's unlikely to be harmful. If this happens, wait at least 24 hours before you take any more.

Taking more than this can be dangerous. If you've taken an accidental overdose you may feel very sleepy, sick or dizzy. You may also find it difficult to breathe. In serious cases you can become unconscious and may need emergency treatment in hospital.

Call 999 if you've taken too much co-codamol and you're finding it difficult to breathe

Call 111 if you've taken too much and feel sleepy, sick or dizzy.

If you need to, go to your nearest accident and emergency (A&E) department straight away.

If you need to go to hospital, take the co-codamol packet or leaflet inside it plus any remaining medicine with you.

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It's safe to take co-codamol with ibuprofen and aspirin.

Don't take co-codamol with paracetamol, or other medicines that contain paracetamol. Co-codamol already contains paracetamol so you could be at risk of paracetamol overdose.

Medicines that have paracetamol in them include painkillers like Tramacet and Co-Dydramol, migraine remedies and some cough and cold remedies (Lemsip and Night Nurse).


Before taking any other medicines, check the label to see whether they contain paracetamol.

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Like all medicines, co-codamol can cause side effects although not everyone gets them. Many people have no side effects or only minor ones.

You are more likely to have side effects if you take the higher strengths of co-codamol.

Common side effects

Common side effects happen in more than 1 in 100 people. Tell your doctor if the side effects bother you or don't go away.

Common side effects include:

  • constipation
  • feeling sick or vomiting
  • feeling sleepy
  • headache

Serious side effects

Serious side effects are rare and happen in less than 1 in 100 people.

Tell a doctor straight away if you have:

  • a skin rash
  • difficulty peeing
  • changes in your eyesight
  • dizziness

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to co-codamol.

Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These aren't all the side effects of co-codamol. For a full list, see the leaflet inside your medicine packet.

You can report any suspected side effect to the UK safety scheme.

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What to do about:

  • constipation - eat more high-fibre foods such as fresh fruit and vegetables and cereals. Try to drink several glasses of water or another non-alcoholic liquid each day. If you can, it may also help to do some gentle exercise.
  • feeling sick or vomiting - take co-codamol with or just after a meal or snack. Feelings of sickness should normally wear off after a few days. Talk to your doctor about taking an anti-sickness medicine if it carries on for longer.
  • feeling sleepy or tired - don't drive or use tools or machinery if you're feeling this way. Don't drink any alcohol as this will make you feel more tired.
  • headaches - make sure you rest and drink plenty of fluids. Don't drink too much alcohol. Talk to your doctor if the headaches last longer than a week or are severe.

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Co-codamol is not generally recommended during pregnancy and while breastfeeding. There may be safer medicines you can take.

Co-codamol contains paracetamol and codeine. While paracetamol is safe to take in pregnancy, codeine is not.

In early pregnancy, codeine has been linked to some problems in the unborn baby. If you take codeine at the end of pregnancy there's a risk that your newborn may get withdrawal symptoms after birth. The baby may also get breathing problems.

For more information about how codeine can affect you and your baby during pregnancy see the Best Use of Medicines in Pregnancy (BUMPS) website.

Co-codamol and breastfeeding

It's not generally recommended for women to take co-codamol while breastfeeding. Small amounts of the codeine in co-codamol get into breast milk and can cause breathing problems in the baby.

Tell your pharmacist or doctor if you're:

  • trying to get pregnant
  • pregnant
  • breastfeeding

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Some medicines interfere with the way co-codamol works. And co-codamol can interfere with the way some medicines work. Tell your doctor if you're taking:

  • sleeping pills or tranquillisers
  • antidepressants - some types don't mix with co-codamol
  • medicines to stop you feeling sick or vomiting such as domperidone or metoclopramide
  • blood-thinning medicines such as warfarin
  • medicines to treat infection, particularly rifampicin or ciprofloxacin
  • epilepsy medicines

Mixing co-codamol with herbal remedies and supplements

It's not possible to say that complementary medicines and herbal teas are safe to take with co-codamol. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.


Tell your pharmacist or doctor if you're taking any other medicines, including herbal remedies, vitamins or supplements.

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How does co-codamol work?

Co-codamol contains paracetamol and codeine. These 2 painkillers work in different ways to relieve pain.

Paracetamol seems to work by blocking chemical messengers in the brain that tell us we have pain. Paracetamol also reduces fever by affecting the chemical messengers in an area of the brain that regulates body temperature.

Codeine belongs to a group of medicines called opiates. It affects pain receptors in the central nervous system and the brain to block pain signals to the rest of the body. When codeine blocks the pain receptors, there are other unwanted effects - for example slow and shallow breathing. It can also slow down digestion, which is why codeine can cause constipation.

When will I feel better?

Co-codamol takes up to 1 hour to work. It keeps on working for about 5 hours.

How long should I take it for?

If you've bought co-codamol from a pharmacy, do not use it for more than 3 days. If your pain hasn't gone away, talk to your pharmacist or doctor.

If your doctor has prescribed co-codamol for you, take it as you've been advised. Depending on why you're taking it, you may need to take it for a few days or weeks at most. For example, if you're in pain after an injury or operation.

You may need to take it for longer if you have a long-term condition such as back pain.

Talk to your doctor if you're not sure how long you need to take co-codamol for.

Is co-codamol addictive?

Yes, taking co-codamol regularly for a long time could make you addicted to the codeine in it. But in reality, if you're taking it as a painkiller under medical supervision, it's very unlikely you will get addicted to it. People who take it as a recreational drug to get 'high' are more likely to become addicted.

How will I know if I'm addicted?

If you're addicted to co-codamol, you may find it difficult to stop taking it or feel you need to take it more often than necessary.

And if you stop taking co-codamol suddenly you may suffer from withdrawal symptoms.

These include:

  • agitation
  • anxiety
  • nervousness
  • panic attacks
  • difficulty sleeping
  • shaking
  • over-activity
  • pins and needles ringing in the ears

Talk to your doctor if you're worried about addiction.

Is it safe to take co-codamol for a long time?

It's not usually recommended to take co-codamol that you've bought from a pharmacy for longer than 3 days.

If you need to take co-codamol for a long time your body can become tolerant to it. That means you need higher doses to control your pain. This isn't usually a problem when you stop taking co-codamol. You can prevent withdrawal symptoms by reducing the co-codamol gradually.

Are there other painkillers I can try?

Yes, there are other painkillers you can try. Some painkillers work better than others for certain pains. For example, the best painkiller to ease your headache may not be the best one for your backache.

Before taking co-codamol, try taking paracetamol to see if that helps your pain. Paracetamol can relieve most types of pain.

Painkillers known as non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, can reduce inflammation as well as pain. These are good for joint, back and muscular pain. However, NSAIDs aren't suitable for some people. This includes people with stomach ulcers or severe heart, kidney or liver problems. If you want to try NSAIDs, speak to your pharmacist or doctor.

Can I drink alcohol with it?

Drinking alcohol while you're taking co-codamol can make you feel more sleepy. It can also increase the risk of serious side effects.

It's best to stop drinking alcohol during the first few days of treatment until you see how co-codamol affects you.

If you feel sleepy with co-codamol, stop drinking alcohol while you're taking it.

Can I drive or ride a bike with it?

Co-codamol can make you feel sleepy or dizzy. If this happens to you, don't drive or ride a bike until you feel better.

Can co-codamol cause weight gain?

There's no evidence that taking co-codamol will make you put on weight or lose it.

Is there any food or drink I need to avoid?

You can eat and drink normally while taking co-codamol.

Will it affect my contraception?

Co-codamol doesn't affect any type of contraception, including contraceptive pills or the morning after pill.

Will it affect my fertility?

Co-codamol can temporarily reduce fertility in men and women.

If you take high doses of co-codamol for a long time it can cause a health problem called hypogonadism. Hypogonadism is where the body doesn't make enough sex hormones. This can make it more difficult for you to conceive.

If you're worried about co-codamol and your fertility, talk to your doctor.

Will recreational drugs affect it?

If you take recreational drugs, such as cannabis, cocaine and heroin, while you're taking co-codamol, you're more likely to get the serious side effects of the codeine in co-codamol. These include breathing difficulties, heart problems, fits and even going into a coma.

Some recreational drugs, such as cannabis, also increase common codeine side effects such as sleepiness and dizziness.

Taking heroin while you're on prescribed co-codamol is especially dangerous. You're more likely to get all the side effects of the codeine in co-codamol, including addiction.

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