Almost everyone with thalassaemia major or other serious types will develop anaemia, which can be life threatening in severe cases.
In anaemia there are low levels of haemoglobin, a substance that transports oxygen, in the blood.
It typically causes:
- tiredness and a general lack of energy
- shortness of breath
- pounding, fluttering or irregular heartbeats (palpitations)
- pale skin
- yellowing of the skin and eyes (jaundice)
Frequent blood transfusions are usually needed for life to stop anaemia becoming severe.
Too much iron in the body
Most people with thalassaemia major or other severe types will also be at risk of developing a range of health problems caused by a build-up of iron in the body. It's usually a side effect of repeated blood transfusions.
Too much iron in the body can cause:
- heart problems – including problems affecting the heart muscle (cardiomyopathy), an irregular heartbeat and heart failure
- swelling and scarring of the liver (cirrhosis)
- delayed puberty
- low levels of oestrogen (in women) or testosterone (in men)
- problems with the thyroid gland (hypothyroidism) and parathyroid glands (hypoparathyroidism)
Lifelong treatment with medicine to stop iron building up to harmful levels will usually be needed. This is known as chelation therapy.
Thalassaemia major or other severe types can also sometimes cause a number of other problems.
- delayed growth during childhood
- small stones in the gallbladder (gallstones), which can cause inflammation of the gallbladder (cholecystitis), tummy (abdominal) pain and jaundice
- unusual bone growth, such as an enlarged forehead or cheeks
- weak, fragile bones (osteoporosis)
- reduced fertility – some people with thalassaemia may need fertility treatment to help them have children