If you have an H. pylori infection, you'll usually be prescribed a course of 2 antibiotics, which each need to be taken twice a day for a week.
The antibiotics most commonly used are amoxicillin, clarithromycin and metronidazole.
The side effects of these antibiotics are usually mild and can include:
- feeling and being sick
- a metallic taste in your mouth
You'll be retested at least 4 weeks after finishing your antibiotic course has been completed to see whether there are any H. pylori bacteria left in your stomach.
If there are, a further course of eradication therapy using different antibiotics may be given.
Proton pump inhibitors (PPIs)
PPIs work by reducing the amount of acid your stomach produces, preventing further damage to the ulcer as it heals naturally. They're usually prescribed for 4 to 8 weeks.
Side effects of these are usually mild, but can include:
These should pass once treatment has been completed.
Like PPIs, H2-receptor antagonists work by reducing the amount of acid your stomach produces.
Ranitidine is the most widely used H2-receptor antagonist for treating stomach ulcers.
Side effects are uncommon, but may include:
Antacids and alginates
All of the above treatments can take several hours before they start to work, so your GP may recommend taking additional antacid medication to neutralise your stomach acid and provide immediate, but short-term, symptom relief.
Some antacids also contain a medicine called an alginate, which produces a protective coating on the lining of your stomach.
These medications are available to buy over the counter at pharmacies. Your pharmacist can advise on which is most suitable for you.
Antacids should be taken when you experience symptoms or when you expect them, such as after meals or at bedtime.
Antacids containing alginates are best taken after meals.
Side effects of both medications are usually minor and can include:
- diarrhoea or constipation
- wind (flatulence)
- stomach cramps
- feeling and being sick
Reviewing NSAID use
If your stomach ulcer has been caused by taking NSAIDs, your GP will want to review your use of them.
You may be advised to use an alternative painkiller not associated with stomach ulcers, such as paracetamol.
Sometimes an alternative type of NSAID that's less likely to cause stomach ulcers, called a COX-2 inhibitor, may be recommended.
If you do need to keep taking it, long-term treatment with a PPI or H2-receptor antagonist may be prescribed alongside the aspirin to try to prevent further ulcers.
It's important to understand the potential risks associated with continued NSAID use.
You're more likely to develop another stomach ulcer and could experience a serious complication, such as internal bleeding.