What causes the loss of nerve cells?
It's not known why the loss of nerve cells associated with Parkinson's disease occurs, although research is ongoing to identify potential causes.
Currently, it's believed a combination of genetic changes and environmental factors may be responsible for the condition.
A number of genetic factors have been shown to increase a person's risk of developing Parkinson's disease, although exactly how these make some people more susceptible to the condition is unclear.
Parkinson's disease can run in families as a result of faulty genes being passed to a child by their parents. But it's rare for the disease to be inherited this way.
Some researchers also feel environmental factors may increase a person's risk of developing Parkinson's disease.
It's been suggested that pesticides and herbicides used in farming and traffic or industrial pollution may contribute to the condition.
But the evidence linking environmental factors to Parkinson's disease is inconclusive.
Other causes of parkinsonism
"Parkinsonism" is the umbrella term used to describe the symptoms of tremors, muscle rigidity and slowness of movement.
Parkinson's disease is the most common type of parkinsonism, but there are also some rarer types where a specific cause can be identified.
These include parkinsonism caused by:
- medication (drug-induced parkinsonism) – where symptoms develop after taking certain medications, such as some types of antipsychotic medication, and usually improve once the medication is stopped
- other progressive brain conditions – such as progressive supranuclear palsy, multiple systems atrophy and corticobasal degeneration
- cerebrovascular disease – where a series of small strokes cause several parts of the brain to die
You can read more about parkinsonism on the Parkinson's UK website.